The C-terminus of MIP-T3 protein is required for ubiquitin-proteasome-mediated degradation in human cells |
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| Authors: | Guo Chao-Wan Liu Ge Xiong Sheng Ge Feng Fuse Takayuki Wang Yi-Fei Kitazato Kaio |
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| Institution: | Division of Molecular Pharmacology of Infectious Agents, Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan. |
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| Abstract: | The intraflagellar transport (IFT) complex is essential for the formation and functional maintenance of eukaryotic cilia which play a vital role in development and tissue homeostasis. However, the biochemical characteristics and precise functions of IFT proteins remain unknown. Here, we report that MIP-T3, a human microtubule-interacting protein recently identified as a novel conserved component of the IFT complex, is an easily degradable protein in human cell lines. Protein degradation is mediated by the ubiquitin-proteasome system, and the C-terminus is required for ubiquitination and proteasome-mediated degradation of MIP-T3 protein. This study provides the first evidence for regulation of IFT protein stability. |
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