A retinal heat shock protein is associated with elements of the cytoskeleton and binds to calmodulin |
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| Authors: | B D Clark I R Brown |
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| Affiliation: | 1. Department of Surgery, School of Medicine, Division of Trauma, Critical Care, Burns and Acute Care Surgery, University of California, San Diego, 92093, La Jolla, CA, USA;2. São Carlos Institute of Chemistry, University of São Paulo, São Paulo, Brazil;3. Department of Neurosciences, School of Medicine, University of California San Diego, 92093, La Jolla, CA, USA |
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| Abstract: | Elevation of body temperature to a level similar to that attained during fever induces a disaggregation of polysomes in the mammalian retina and induction of a 74K heat shock protein (hsp74). Induced retinal hsp74 copurifies with twice cycled microtubules and also with purified intermediate filaments, is precipitated by antibodies prepared against purified Tau proteins and binds to calmodulin. |
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