Biphenyls as potent vitronectin receptor antagonists. |
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| Authors: | Klaus Urbahns Michael H?rter Markus Albers Delf Schmidt Beatrix Stelte-Ludwig Ulf Brüggemeier Andrea Vaupel Christoph Gerdes |
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| Affiliation: | Institute of Medicinal Chemistry, Pharma Research Centre, Bayer AG, D-42096 Wuppertal, FRG. klaus.urbahns.ku1@bayer.co.jp |
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| Abstract: | Vitronectin receptor (alpha(V)beta(3)) antagonism has been implicated as a mechanism for the treatment of restenosis following balloon angioplasty. In this work we present results from screening of a focused combinatorial library based on a biphenyl moiety. Our SAR studies led to the identification of compounds with subnanomolar activity, selectivity towards the related GPIIbIIIa receptor and functional activity on human smooth muscle cell migration. |
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