| Abstract: | Bovine lymphocytotoxicity tests with 20 unabsorbed bovine blood group sera revealed extensive reactivity which in the majority of cases had no indication of blood group relationship. Six of these sera were absorbed with selected lymphocytes to produce eleven antisera of reduced specificity. Again, most of the sera had reaction patterns which could not be related to the hemolytic patterns of any known blood group antibodies. However, five comparisons involving unabsorbed antisera and two comparisons involving absorbed antisera provided statistical evidence of similarities between their lymphocytotoxic reaction patterns and the hemolytic reaction patterns of certain blood group antibodies. Several of the sera appeared to contain related cytotoxic specificities, and three such absorbed sera may have contained an anti-J specificity. All six examined monospecific isoimmune blood group antisera contained lymphocytic reactivities not related to their hemolytic specificities. Two normal sera containing naturally occurring anti-J had no cytotoxic activity. Anti-semen sera likewise were devoid of lymphocytotoxic activity. |
