Effects of host endocrine gland removal on the permissive status of laboratory rodents to infection by Schistosoma mansoni |
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Authors: | P.M. Knopf M. Soliman |
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Affiliation: | Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912 U.S.A. |
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Abstract: | Knopf P. M. and Soliman M. 1980. Effects of host endocrine gland removal on the permissive status of laboratory rodents to infection by Schistosoma mansoni. International Journal for Parasitology, 10: 197–204. The capacity of Schistosoma mansoni to complete its life cycle was compared in CD-1 mice (permissive hosts) and Sprague-Dawley rats (nonpermissive hosts) from which the pituitary gland had been removed prior to infection with cercariae. Except for a modest decrease in egg burden, none of the parameters of worm life cycle assessed were affected in hypophysectomized mice. In contrast, all these parameters were affected in hypophysectomized rats, e.g. onset of adult worm elimination was delayed, worm development improved, oviposition increased and miracidia developed. Effects of removal from rats of the thyroid/parathyroid glands on the parasite life cycle were similar to hypophysectomy; adrenalectomy or gonadectomy were without affect. Differences between thyroidectomized and thymectomized rats are discussed. It is concluded that host hormones contribute to the nonpermissive status of rats to Schistosoma mansoni infections. |
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Keywords: | trematode Sprague-Dawley rats hypophysectomy thyroidectomy adrenalectomy gonadectomy permissive host nonpermissive host adult worm elimination vitelline glands oviposition miracidia |
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