Resistance and susceptibility in human onchocerciasis--beyond Th1 vs. Th2 |
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Authors: | Hoerauf Achim Brattig Norbert |
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Affiliation: | Bernhard Nocht Institute of Tropical Medicine, Bernhard-Nocht-Strasse 74, 20359, Hamburg, Germany. hoerauf@bni.uni-hamburg.de |
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Abstract: | As research progress has led to programs for the elimination of onchocerciasis as a public health problem, research must now be intensified to protect elimination efforts. A profound understanding of the immunology in the human-parasite relationship is required for predicting the impacts of an altered immune response in a population post-microfilaricide treatment, and for the development of a vaccine against onchocerciasis, a highly desirable tool to guarantee sustained elimination success. This article summarizes the recent advancements in understanding the human immune mechanisms against onchocerciasis, and focuses on the new concept of T-cell suppressor responses as a major counterbalance mechanism for effector responses driven by T helper 1 and T helper 2 cells against the filarial worms. |
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