Safrole oxide induces apoptosis by activating caspase-3, -8, and -9 in A549 human lung cancer cells |
| |
Authors: | Du Aiying Zhao Baoxiang Yin Deling Zhang Shangli Miao Junying |
| |
Affiliation: | Institute of Developmental Biology, School of Life Science, Shandong University, Jinan 250100, China. |
| |
Abstract: | Previously we found that 3,4-(methylenedioxy)-1-(2',3'-epoxypropyl)-benzene (safrole oxide) induced a typical apoptosis in A549 human lung cancer cells. In this study, we further investigated which caspases were activated by safrole oxide during the apoptosis. The data showed that the activity of caspase-3, -8, and -9 was significantly enhanced by the compound, which suggested that safrole oxide might be used as a caspase promoter to initiate lung cancer cell apoptosis. |
| |
Keywords: | |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|