Social status modifies estradiol activation of sociosexual behavior in female rhesus monkeys |
| |
Affiliation: | 1. SATIE, UMR 8029, École Normale Supérieure de Cachan, Cachan, France;2. CAOR, Mines Paristech, 60 boulevard Saint-Michel, 75006 Paris,;3. Communication Systems Group, Technische Universität, Darmstadt, Germany;4. IUT de Ville d’Avray, University of Paris Ouest Nanterre La Défense, Lemé EA 4416, France;5. Laboratoire des Signaux et Systèmes (L2S), University of Paris-Sud, Gif-sur-Yvette, France;6. Netherlands Institute for Radio Astronomy (ASTRON), P.O. Box 2, Dwingeloo NL-7990 AA, The Netherlands;1. Tobacco Control Unit, Cancer Control and Prevention Programme, Institut Català d''Oncologia-ICO, Gran Via de L''Hospitalet 199-201, 08908 L''Hospitalet de Llobregat Barcelona, Spain;2. Philip R. Lee Institute for Health Policy Studies, University of California, San Francisco, United States;3. Cancer Prevention and Control Group, Institut d''Investigació Biomèdica de Bellvitge — IDIBELL, Barcelona, Spain;4. Medicine and Health Sciences School, Universitat Internacional de Catalunya, Barcelona, Spain;5. Tobacco Control Programme, City and Hackney Public Health Service, London Borough of Hackney, UK;6. Biostatistics Unit, Department of Basic Science, Universitat Internacional de Catalunya, Sant Cugat del Vallès, Spain;7. Department of Clinical Sciences, School of Medicine, Campus of Bellvitge, Universitat de Barcelona, L''Hospitalet de Llobregat, Spain;1. University of Lleida, Spain;2. Institute of Biomedical Research of Lleida (IRB Lleida), Spain;3. Autonomous University of Madrid, Spain;4. European University of Madrid, Spain |
| |
Abstract: | Estrogen (E2) has activational effects on sexual motivation and mitigating effects on anxiety-like behaviors that can be attenuated with chronic exposure to psychosocial stress. Some studies suggest that this attenuation can be overcome by higher doses of E2, while others show that chronic psychosocial stress may alter the mechanisms of E2 function, thus reducing any positive benefit from higher doses of E2. To determine the interaction between psychosocial stress and E2 dose on behavior, we examined the scope of attenuation across a suite of socioemotional behaviors, including reproduction, affiliation, aggression, submission, and anxiety-like behaviors on 36 ovariectomized female rhesus monkeys. Females were exposed to graded psychosocial stress, established by an intrinsic female dominance hierarchy, where subordinate animals receive high amounts of harassment. Our data show that E2 dose-dependently increased sexual motivation and male-affiliation in dominant (e.g. low-stress) females, while subordinate females showed no positive effects of E2, even at higher doses. In addition, contact aggression was attenuated in dominant females, while non-contact aggression was attenuated in both dominant and middle-ranking females. These results suggest that the stress-induced attenuation of E2's activational effects on sexual behavior and affiliation with males may not be overcome with higher doses of E2. Furthermore, the observed behavioral consequences of psychosocial stress and E2 dose may be dependent on the behaviors of all the females in the social-group, and better resolution on these effects depends on isolating treatment to individuals within the group to minimize alterations in social-group interactions. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|