Retinoic acid signalling in the development of branchial arches |
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| Authors: | Mark Manuel Ghyselinck Norbert B Chambon Pierre |
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| Affiliation: | Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Institut Clinique de la Souris (ICS), CNRS/INSERM/ULP, Collège de France, BP10142, 67404 Illkirch Cedex, CU de Strasbourg, France. marek@igbmc.u-strasbg.fr |
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| Abstract: | Branchial arches develop through a complex sequence of interactions between migrating cells, derived from neural crest and mesoderm, and epithelia of ectodermal and endodermal origin, to yield a variety of derivatives, notably skeletal elements, arteries and glands. In all vertebrate species, dramatic malformations generated by experimental blocks or activations of retinoic acid signalling highlight key roles for this molecule in the endoderm for branchial arch formation and morphogenesis. |
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