THE EFFECT OF METHYL CCNU (NSC-95441) ON THE CELLULAR KINETICS OF NORMAL AND LEUKEMIC MURINE TISSUES IN VIVO |
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| Authors: | Robert C. Young |
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| Affiliation: | Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland |
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| Abstract: | The effect of MeCCNU on the cellular kinetics of normal and leukemic murine tissues is examined in vivo . A prolongation in the S phase is noted after doses of MeCCNU as low as 4 mg/kg, and this prolongation persists for approximately 4 hr after the dose. No persistent alteration in the growth fraction is produced by MeCCNU. The generation time of the cells regrowing after MeCCNU is slightly prolonged, compared to normal L1210 leukemia. Simultaneous studies on ascites tumor, normal bone marrow, and normal gastrointestinal mucosa, using the in vivo uptake of 3H-thymidine into DNA, have shown a differential effect on the tumor and normal tissues. |
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