Hyper-recombination in dam mutants of Escherichia coli K-12 |
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| Authors: | M. G. Marinus and E. Bruce Konrad |
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| Affiliation: | (1) Dept. of Pharmacology, University of Massachusetts Medical School, 01605 Worcester, MA;(2) Dept. of Biochemical Pharmacology, N.I.A.M.D.D., National Institutes of Health, 20014 Bethesda, MD |
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| Abstract: | Summary F-prime heterogenotes of dam-3 bacteria segregate F-prime homogenotes at a frequency 30–200 times higher than the isogenic dam+ strain. A hyperrecombination mutant which shows increased recombination between chromosomal duplications was characterized as a dam mutant. The dam-3 allele causes a reduction in linkage of proximal unselected markers in transconjugants and increases the recombination frequency between a pair of closely linked markers. It is concluded that dam mutations confer a hyperrecombination phenotype to the cell. |
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