Influence of Ca++ and Mg++ on the vanadate inhibition of the Ca++- ATPase from pig heart sarcoplasmic reticulum |
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Authors: | R Wierichs A Hagenmeyer H Bader |
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Institution: | Department of Pharmacology and Toxicology, University of Ulm, D - 7900 Ulm, Oberer Eselsberg, FRG |
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Abstract: | Vanadate inhibits the Ca++-ATPase of sarcoplasmic reticulum from pig heart half maximally at about 10?5 M. Mg++ promotes this inhibition by vanadate whereas increasing Ca++-concentrations protect the enzyme against vanadate inhibition. Keeping the ratio constant there was no influence of ATP on the vanadate inhibition at concentrations up to 5 × 10?3 M ATP. Whenever the ratio was higher than 1:1 the inhibitory effect of vanadate on the Ca++-ATPase was increased. |
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