|
|||||
|
|
Design, synthesis, and SAR studies on a series of 2-pyridinylpiperazines as potent antagonists of the melanocortin-4 receptor |
|
| Authors: | Tran Joe A Pontillo Joseph Fleck Beth A Marinkovic Dragan Arellano Melissa Tucci Fabio C Lanier Marion Saunders John Jiang Wanlong Chen Caroline W Foster Alan C Chen Chen |
| Affiliation: | Department of Medicinal Chemistry, Neurocrine Biosciences, Inc., 12790 El Camino Real, San Diego, CA 92130, USA. |
| Abstract: | A series of 2-pyridinylpiperazines derived from beta-Ala-(2,4-Cl)Phe dipeptide was synthesized for the study of their SARs and possible interactions with the MC4 receptor. Compounds such as 11k (Ki=6.5 nM) possessed high potency. |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |