Growth hormone stimulates hypothalamic somatostatin. |
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Authors: | Y C Patel |
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Affiliation: | Fraser Laboratories Royal Victoria Hospital, McGill University Montreal, Quebec H3A 1A1, Canada |
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Abstract: | Hypothalamic somatostatin concentration is increased in normal rats treated with growth hormone. Somatostatin is reduced in the median eminence of hypophysectomized rats but restored to normal following growth hormone administration. These results suggest that growth hormone exerts a positive feedback effect on hypothalamic somatostatin mechanism by which it may regulate its own secretion. |
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