Heme oxygenase-1 (HO-1), a protective gene that prevents chronic graft dysfunction |
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| Authors: | Camara Niels Olsen Saraiva Soares Miguel Parreira |
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| Affiliation: | 1. Department of Sport and Exercise Science, Faculty of Science, University of Portsmouth, Guildhall Walk, Portsmouth PO1 2ER, United Kingdom;2. Department Sport and Exercise Science, Institute for Sport, University of Chichester, College Lane, Chichester, West Sussex PO19 6PE, United Kingdom;3. Department of Psychology, Faculty of Health and Life Sciences, Northumbria University, Northumberland Road, Newcastle-upon-Tyne NE1 8ST, United Kingdom;4. Department of Sport, Health and Nutrition, Leeds Trinity University, Brownberrie Lane, Horsforth, LS18 5HD, United Kingdom |
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| Abstract: | Heme oxygenase-1 (HO-1) is a stress-responsive enzyme that acts during inflammatory reactions as the rate-limiting step in the catabolism of heme, yielding equimolar amounts of iron (Fe), biliverdin, and the gas carbon monoxide (CO). Expression of HO-1 regulates inflammatory and immune responses, such as those involved in the rejection of transplanted organs. We will discuss here accumulating evidence supporting the notion that expression of HO-1 in a transplanted organ can prevent its rejection. We will argue that the protective effects exerted by HO-1 are mediated to a large extent by the end products that it generates via the catabolism of heme. Better knowledge of how to enhance these protective effects is likely to help create new therapeutic strategies to improve the outcome of transplanted organs. |
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