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alpha-Glucosidase inhibitory constituents from stem bark of Terminalia superba (Combretaceae)
Authors:Wansi Jean Duplex  Lallemand Marie-Christine  Chiozem David Daco  Toze Flavien Aristide A  Mbaze Luc Meva'a  Naharkhan Shamsun  Iqbal Muhammad Choudhary  Tillequin François  Wandji Jean  Fomum Zacharias Tanee
Affiliation:Department of Chemistry, University of Douala, Faculty of Science, P.O. Box 24157, Douala, Cameroon. jdwansi@yahoo.fr
Abstract:The CH(2)Cl(2)/CH(3)OH (1/1) extract of the dried stem bark of Terminalia superba afforded two compounds, (7S,8R,7'R,8'S)-4'-hydroxy-4-methoxy-7,7'-epoxylignan and meso-(rel 7S,8R,7'R,8'S)-4,4'-dimethoxy-7,7'-epoxylignan along with 11 known compounds. The structures of the compounds were established by analysing the spectroscopic data and also comparing it with the data of previously known analogues. All the isolated compounds were evaluated for their glycosidase inhibition activities. Gallic acid and methyl gallate showed significant alpha-glucosidase inhibition activity.
Keywords:Terminalia superba   Combretaceae   Stem bark   Lignans   Gallic acid   α-Glucosidase activity
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