A Misclassification Model for the Non‐Disjunction Fraction in Meiosis I |
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Authors: | Rosangela H. Loschi João V. D. Monteiro Cristiane S. Souto |
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Affiliation: | Departamento de Estatística – ICEx, Universidade Federal de Minas Gerais, Av. Ant?nio Carlos 6627, Pampulha, 31 270‐901 Belo Horizonte, MG, Brazil |
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Abstract: | In this paper we introduce a misclassification model for the meiosis I non‐disjunction fraction in numerical chromosomal anomalies named trisomies. We obtain posteriors, and their moments, for the probability that a non‐disjunction occurs in the first division of meiosis and for the misclassification errors. We also extend previous works by providing the exact posterior, and its moments, for the probability that a non‐disjunction occurs in the first division of meiosis assuming the model proposed in the literature which does not consider that data are subject to misclassification. We perform Monte Carlo studies in order to compare Bayes estimates obtained by using both models. An application to Down Syndrome data is also presented. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim) |
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Keywords: | Bayes estimator Classification errors Multinomial distribution Non‐informative priors Trisomy |
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