Influence of coinfecting pathogens on HIV expression: evidence for a role of Toll-like receptors |
| |
| Authors: | Báfica André Scanga Charles A Schito Marco Chaussabel Damien Sher Alan |
| |
| Institution: | Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 50, Rm. 6146, 50 South Drive, Bethesda, MD 20892, USA. abafica@niaid.nih.gov |
| |
| Abstract: | Immune activation of HIV gene expression as a consequence of the host response to coinfecting pathogens has been implicated as an important factor in AIDS progression. Immune responsiveness to many of the infectious agents associated with HIV has been demonstrated to depend on a family of innate recognition molecules, known as Toll-like receptors (TLR). Therefore, TLR-pathogen interactions could play an indirect role in regulating HIV-associated disease. In this review, we summarize emerging evidence for the influence of TLR recognition on HIV gene activation and AIDS progression. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
