绒毛膜促性腺激素及孕酮对大鼠小肠移行性综合肌电的影响

于去卵巢大鼠小肠的不同部位植入铂金丝单极电极,观察了绒毛膜促性腺激素(HCG)及孕酮对其移行性综合肌电(MMC)的影响。结果为:(1) 静注HCG后,十二指肠及空肠上段出现典型的与妊娠有关的MMC改变,即MMC的周期被间断出现且不规则延长的Ⅱ相所打乱。(2) 肌注孕酮后,十二指肠MMC的Ⅰ相和Ⅱ相时程均显著延长,但MMC的周期性无明显紊乱。(3) 在肌注孕酮的基础上加注HCG后,MMC的变化在特征上与单独注射HCG时相同,在范围上扩大到整个小肠。上述结果提示,在大鼠,HCG可引起典型的与妊娠有关的MMC活动紊乱;当有孕酮存在时,HCG的这一效应进一步增强。

EFFECTS OF HUMAN CHORIONIC GONADOTROPHIN AND PROGESTERONE ON SMALL INTESTINAL MIGRATING MYOELECTRIC COMPLEX IN RATS

The effects of human chorionic gonadotrophin (HCG) and progesterone (P) on migrating myoelectric complex (MMC) of the small intestine in ovariectomized rats were investigated by implanted monopolar-electrode in the intestinal wall of the duodenum, jejunum and ileum. The results showed (1) after i.v. administration of HCG the periodicity of the duodenal and upper jejunal MMC was interrupted by irregularly prolonged phases II occurring intermittently; (2) after i.m. administration of P the duration of phases I and II of the duodenal MMC was significantly prolonged, but the periodicity was not affected; (3) the effect of P plus HCG on MMC was similar to that of HCG alone, but the combined effect was spread over the whole small intestine. These results suggest that HCG can induce remarkable changes of the small intestinal MMC, which are similar to those observed in pregnant rats. In the presence of P, the effect of HCG is enhanced markedly.