Intracellular generation of electronically excited states. Polymorphonuclear leukocytes challenged with a precursor of triplet acetone

When the enol of isobutanal is added to polymorphonuclear cells, it undergoes an intracellular, myeloperoxidase-catalyzed aerobic oxidation with the formation of triplet acetone. The latter induces considerable damage if the enol concentration exceeds 2 mM. Cells which do not have myeloperoxidase are not damaged.