Integrin triplets of marine sponges in human D2 receptor heteromers |
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| Authors: | Tarakanov Alexander O Fuxe Kjell G Borroto-Escuela Dasiel O |
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| Institution: | Russian Academy of Sciences, St. Petersburg Institute for Informatics and Automation, Saint Petersburg, Russia. tar@iias.spb.su |
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| Abstract: | The evidence for the existence of receptor heteromers opens up a new field for a better understanding of neural transmission. Based on our theory, we have discovered main triplets of amino acid residues in cell-adhesion receptors of marine sponges, which appear also as homologies in several dopamine D2 receptor heteromers of human brain. The obtained results probably mean a general molecular mechanism for receptor-receptor interactions in heteromers originated from the lowest animals (marine sponges). |
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