Effect of BUdR on proliferation and development of cytotoxicity in mixed leukocyte culture |
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| Authors: | W Clark J Nedrud |
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| Affiliation: | Dept. of Biology and Molecular Biology Institute, University of California, Los Angeles, California 90024 U.S.A. |
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| Abstract: | The effect of the thymidine analog, 5-bromo-2′-deoxyuridine (BUdR) on the proliferation of, and development of cytotoxicity in, mouse lymphocytes in mixed leukocyte culture was measured. It was found that BUdR inhibited the development of cytotoxicity only to the extent that it inhibited mitosis. This is in contrast to the effect of BUdR in differentiating cell systems, where differentiation can be inhibited by concentrations of BUdR that do not inhibit cell proliferation. Possible implications of these results are discussed. |
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