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Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns |
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| Authors: | Karol Szafranski Stefanie Schindler Stefan Taudien Michael Hiller Klaus Huse Niels Jahn Stefan Schreiber Rolf Backofen Matthias Platzer |
| Affiliation: | (1) Genome Analysis, Leibniz Institute for Age Research - Fritz Lipmann Institute, Beutenbergstr., 07745 Jena, Germany;(2) Institute of Computer Science, Bioinformatics Group, Albert-Ludwigs-University Freiburg, Georges-Koehler-Allee, 79110 Freiburg, Germany;(3) Institute of Clinical Molecular Biology, Christian Albrechts University Kiel, Schittenhelmstr., 24105 Kiel, Germany |
| Abstract: | BackgroundDespite some degeneracy of sequence signals that govern splicing of eukaryotic pre-mRNAs, it is an accepted rule that U2-dependent introns exhibit the 3' terminal dinucleotide AG. Intrigued by anecdotal evidence for functional non-AG 3' splice sites, we carried out a human genome-wide screen. |
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