Synthesis of 13C-labeled steroid hormones |
| |
Authors: | G Zomer J F Stavenuiter |
| |
Institution: | National Institute of Public Health and Environmental Protection, Bilthoven, The Netherlands. |
| |
Abstract: | The synthesis of 13C-labeled steroid hormones is reviewed. Two general approaches are highlighted: partial synthesis in which part of the steroid nucleus is replaced with 13C-labeled synthons, and total synthesis. Examples from both approaches, leading to (3-(3)C)-, (4-(13)C)-, (3,4-(13)C2)-, and (1,2,3,4-(13)C4)- labeled steroid hormones (e.g., testosterone, estradiol, progesterone, and cortisol), are presented. |
| |
Keywords: | |
|
|