Inhibition of tumor growth in mice treated with synthetic muramyl dipeptide |
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| Authors: | J. Bubeník J. Ježek M. Zaoral J. Hofmann Y. V. Gruntenko J. G. Osipov A. G. Zolotareva T. E. Vakhrusheva V. G. Budker |
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| Affiliation: | (1) Institute of Molecular Genetics, Czechoslovak Academy of Sciences, Flemingovo nám. 2, Prague 6, Czechoslovakia;(2) Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, Flemingovo nám. 2, Prague 6, Czechoslovakia;(3) Institute of Cytology and Genetics, Siberian Branch of the USSR Academy of Sciences, Novosibirsk 90, USSR;(4) Institute of Organic Chemistry, Siberian Branch of the USSR Academy of Sciences, Novosibirsk 90, USSR |
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| Abstract: | Summary Treatment with synthetic MDP inhibited growth of transplantable, chemically induced tumors in syngeneic mice. The tumor-inhibitory effect was dependent on the schedule of MDP administration.Growth of SC transplants of a nonmetastasizing, MC-induced fibrosarcoma, MC11, was inhibited by local treatment with 200  g and 1,000 g MDP given SC 5–7 weeks before challenge. Treatment with lower (10 g and 100 g) doses of MDP and shorter (1–4 weeks) time intervals was not effective. Single doses of MDP (10–1,000 g) 1–3 weeks after challenge had no effect.Growth of IV-inoculated, metastasizing AAT-induced hepatoma A was inhibited by IV injections of 20 g MDP given 1 and 2 days prior to the challenge. Significant increases in the survival of hepatoma-bearing mice were observed only after injections of MDP incorporated in multilamellar liposomes.Abbreviations MDP n-acetylmuramyl-l-alanyl-d-isoglutamine - B10 C57BL/10ScSnPh mice - MC 3-methylcholanthrene - ATT o-amino-azotoluene - PBS phosphate-buffered saline |
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