Effect of arsenic (AsIII) on glutathione-dependent enzymes in liver and kidney of the freshwater fish Channa punctatus |
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Authors: | Tanu Allen S. V. S. Rana |
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Affiliation: | (1) Toxicology Laboratory, Department of Zoology, Ch. Charan Singh University, 250004 Meerut, India;(2) Department of Environment Science, Ch. Charan Singh University, 250004 Meerut, India |
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Abstract: | The possible role of glutathione-dependent enzymes in the liver and kidney of the freshwater fish Channa punctatus has been studied after exposure to arsenic trioxide for different durations. Activities of glutathione-S-transferases, glutathione peroxidase, glutathione reductase, and catalase decreased in the liver and kidney as a result of the initial increase in arsenic concentration in the liver and kidney. However, during longer exposures, a decline in arsenic concentration corresponded with improved enzyme activity. Because arsenic manifests its toxicity by inducing oxidative stress, the antioxidant enzymes, especially the glutathione-dependent enzymes, play a protective role in arsenic toxicity. |
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Keywords: | Arsenic liver kidney fish phase II enzymes |
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