Activity of rifampin plus trimethoprim againstHaemophilus influenzae |
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| Authors: | Marisa Berti Roberto Scotti Franca Ripamonti Vittorio Arioli |
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| Institution: | (1) Chemotherapy Department, Gruppo Lepetit SpA, Via G. Durando, 38, I-20158 Milano, Italy |
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| Abstract: | The activity of the combination rifampin plus trimethoprim againstHaemophilus influenzae was studied from the point of view of synergism, bactericidal activity, and inhibition of the selection of rifampin-resistant
cells. At concentrations of the two drugs that are easily attainable in human serum after oral treatment with 600 mg of rifampin
plus 160 mg of trimethoprim, the combination acted synergistically on all of the strains tested, was remarkably bactericidal,
and inhibited the selection of rifampin-resistant cells. |
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