DNA Polymerase Activity associated with Purified Kilham Rat Virus |
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Authors: | LOIS ANN SALZMAN |
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Institution: | 1.National Institutes of Allergy and Infectious Diseases, Laboratory of Biology of Viruses, National Institutes of Health,Bethesda |
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Abstract: | RNA tumour viruses contain an enzyme which can transcribe DNA from an RNA template1,2, an endonuclease and a DNA-dependent DNA polymerase activity3,4. RNA polymerase has been reported in vaccinia virus5,6, reovirus7,8 and cytoplasmic polyhidrosis virus9. I wish to describe a DNA polymerase activity associated with a highly purified preparation of the parvovirus, Kilham rat virus (KRV), which is thus the first report of a DNA polymerase associated with a DNA virus. KRV, a small virus first isolated from a rat sarcoma10, is antigenically related to the H viruses isolated from human transplantable tumours11. Those parvoviruses which have been characterized all contain single stranded DNA with molecular weights of 1.5 to 2.5 × 106 (refs. 12,13 and 14). |
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