Comparative kinetic study of the binding between 2,3,7,8-tetrachlorodibenzo-ρ-dioxin and related ligands with the hepatic Ah receptors from several rodent species |
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| Authors: | Jamie S Nakai Martha J Winhall Nigel J Bunce Rhonda Rosengren Stephen Safe |
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| Institution: | 1. Guelph-Waterloo Centre for Graduate Work in Chemistry, Department of Chemistry and Biochemistry, University of Guelph, Guelph, Ontario, Canada, NIG 2W1;2. Department of Veterinary Physiology and Pharmacology, Texas A & M University, College Station, TX. 77843–4466 |
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| Abstract: | Kinetic analysis of the time course of association of 3H]-2,3,7,8-tetrachlorodibenzo-ρ-dioxin with hepatic cytosoi from five rodent species gave additional evidence for differences in the properties of the Ah receptor ligand binding subunit between species. A parallel study of the association of six tritiated polychlorinated dibenzopρ-dioxins and dibenzofurans with hepatic Ah receptor from Wistar rat and C57BL/6 mouse showed that their rank order for kinetic affinity did not correlate with the rank ordering of their toxic potency- and may vary according to the source of the Ah receptor. |
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| Keywords: | Ah Receptor TCDD PCDDs PCDFs Kinetics |
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