A comparison in association and linkage genome-wide scans for alcoholism susceptibility genes using single-nucleotide polymorphisms |
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| Authors: | Chiu Yen-Feng Liu Su-Yun Tsai Ya-Yu |
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| Affiliation: | Division of Biostatistics and Bioinformatics, National Health Research Institutes, Miaoli, Taiwan, ROC. yfchiu@nhri.org.tw |
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| Abstract: | We conducted genome-wide linkage scans using both microsatellite and single-nucleotide polymorphism (SNP) markers. Regions showing the strongest evidence of linkage to alcoholism susceptibility genes were identified. Haplotype analyses using a sliding-window approach for SNPs in these regions were performed. In addition, we performed a genome-wide association scan using SNP data. SNPs in these regions with evidence of association (P
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