OTUB1 co-opts Lys48-linked ubiquitin recognition to suppress E2 enzyme function期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

OTUB1 co-opts Lys48-linked ubiquitin recognition to suppress E2 enzyme function

Authors:	Juang Yu-Chi Landry Marie-Claude Sanches Mario Vittal Vinayak Leung Charles C Y Ceccarelli Derek F Mateo Abigail-Rachele F Pruneda Jonathan N Mao Daniel Y L Szilard Rachel K Orlicky Stephen Munro Meagan Brzovic Peter S Klevit Rachel E Sicheri Frank Durocher Daniel

Affiliation:	Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.

Abstract:	Download : Download high-res image (250KB) Download : Download full-size image Highlights? Identification of OTUB1 mutants with impaired ability to inhibit E2 enzymes ? Crystal structure of a ubiquitin-charged E2 bound to OTUB1 ? Molecular basis of Lys48-linked ubiquitin chain recognition by OTUB1 determined ? OTUB1 employs product inhibition mimicry to inhibit E2 enzymes

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