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The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type
Authors:Yuneva Mariia O  Fan Teresa W M  Allen Thaddeus D  Higashi Richard M  Ferraris Dana V  Tsukamoto Takashi  Matés José M  Alonso Francisco J  Wang Chunmei  Seo Youngho  Chen Xin  Bishop J Michael
Institution:G.W. Hooper Research Foundation, University of California, San Francisco, San Francisco, CA 94143, USA. mariia.yuneva@ucsf.edu
Abstract:
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  • Highlights? MYC and MET affect glucose and glutamine metabolism differently in the liver ? Tissue context affects the outcome of metabolic reprogramming by MYC ? MYC overexpression sensitizes cells to inhibition of Gls1 glutaminase
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