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Protein model discrimination using mutational sensitivity derived from deep sequencing

Authors:	Adkar Bharat V Tripathi Arti Sahoo Anusmita Bajaj Kanika Goswami Devrishi Chakrabarti Purbani Swarnkar Mohit K Gokhale Rajesh S Varadarajan Raghavan

Institution:	Molecular Biophysics Unit, Indian Institute of Science, Bangalore-560012, India.

Abstract:	Download : Download high-res image (318KB) Download : Download full-size image Highlights? Individual mutant phenotypes in a saturation library derived via deep sequencing ? Residue depth and active-site residue derivation from mutant phenotypes ? Mutant-phenotype-derived parameters used for protein model discrimination ? Derivation of sequence-structure-function relationships without protein isolation

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