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Imprinted gene dosage is critical for the transition to independent life

Authors:	Charalambous Marika Ferron Sacramento R da Rocha Simao T Murray Andrew J Rowland Timothy Ito Mitsuteru Schuster-Gossler Karin Hernandez Arturo Ferguson-Smith Anne C

Institution:	Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK. mc524@cam.ac.uk

Abstract:	Download : Download high-res image (266KB) Download : Download full-size image Highlights? Correct dosage of chromosome 12-imprinted genes is essential for postnatal survival ? Disruption of Dlk1 and Dio3 imprinting causes failure to adapt to independent life ? Maximal brown adipose activity is required as animals first leave the nest ? Dlk1 and Dio3 regulate maturation of brown adipose tissue

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