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Mutational tipping points for switching protein folds and functions

Authors:	He Yanan Chen Yihong Alexander Patrick A Bryan Philip N Orban John

Institution:	1. Institute for Bioscience and Biotechnology Research, University of Maryland College Park, 9600 Gudelsky Drive, Rockville, MD 20850, USA;2. Department of Bioengineering, University of Maryland College Park, 9600 Gudelsky Drive, Rockville, MD 20850, USA;3. Department of Chemistry and Biochemistry, University of Maryland College Park, 9600 Gudelsky Drive, Rockville, MD 20850, USA

Abstract:	Download : Download high-res image (181KB) Download : Download full-size image Highlights? Switching between 3α and 4β+α folds can occur in multiple ways ? Single-residue mutations at diverse positions can induce fold switching ? Mutations lead to a near-complete shift in equilibrium between the two folds ? New function can be gained before the relevant fold is significantly populated

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