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hnRNP A1 proofreads 3' splice site recognition by U2AF
Authors:Tavanez Joao Paulo  Madl Tobias  Kooshapur Hamed  Sattler Michael  Valcárcel Juan
Affiliation:Centre de Regulació Genòmica, Dr. Aiguader 88, 08003 Barcelona, Spain; Universitat Pompeu Fabra, Dr. Aiguader 88, 08003 Barcelona, Spain.
Abstract:
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  • Highlights? hnRNP A1 displaces U2AF from uridine-rich RNAs not followed by a 3′ splice site AG ? A 3′ splice site AG allows formation of a ternary complex with hnRNP A1 and U2AF ? AG proofreading requires U2AF35 and the glycine-rich domain of hnRNP A1 ? hnRNP A1-mediated proofreading influences U2 snRNP recruitment
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