The anomeric mixture of some O-galactolipid derivatives is more toxic against cancer cells than either anomer alone |
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Authors: | Song Shao-Xing Wu Ming-Li He Xiao-Peng Zhou Yu-Bo Sheng Li Li Jia Chen Guo-Rong |
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Affiliation: | Key Laboratory for Advanced Materials & Institute of Fine Chemicals, East China University of Science and Technology, Shanghai 200237, PR China. |
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Abstract: | The anomeric mixture of a series of O-galactolipid derivatives is revealed to be more toxic against several cancer cell lines than their either single component with the pure α- or β-configuration. This interesting phenomenon has been confirmed on pairs of synthesized O-galactosyl anomers bearing length-varied alkyl chains at the lipid end. Furthermore, the most potent mixture was determined inoffensive to a normal cell line tested. |
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