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The anomeric mixture of some O-galactolipid derivatives is more toxic against cancer cells than either anomer alone
Authors:Song Shao-Xing  Wu Ming-Li  He Xiao-Peng  Zhou Yu-Bo  Sheng Li  Li Jia  Chen Guo-Rong
Affiliation:Key Laboratory for Advanced Materials & Institute of Fine Chemicals, East China University of Science and Technology, Shanghai 200237, PR China.
Abstract:The anomeric mixture of a series of O-galactolipid derivatives is revealed to be more toxic against several cancer cell lines than their either single component with the pure α- or β-configuration. This interesting phenomenon has been confirmed on pairs of synthesized O-galactosyl anomers bearing length-varied alkyl chains at the lipid end. Furthermore, the most potent mixture was determined inoffensive to a normal cell line tested.
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