Antioxidant activity of Arthritin--a polyherbal formulation |
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Authors: | Chamundeeswari D Vaijayanthi V Umamaheswari S Gandhimathi C Karna S L Rajasekar Meignanam E Vasantha J |
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Institution: | Sri Ramachandra College of Pharmacy, Sri Ramachandra Medical College and Research Institute (Deemed University), Porur, Chennai 600 116, India. |
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Abstract: | In complete freund's adjuvant induced arthritis in male albino rats, a significant increase in serum lipid peroxidase besides increase in paw swelling and a significant decrease in superoxide dismutase, glutathione peroxidase and total reduced glutathione levels were observed. Arthritin produced a marked reversal of these enzyme levels, besides a significant reduction in paw swelling. The results suggest that, the polyherbal formulation 'Arthritin' exerts its effects by modulating lipid peroxidation and enhancing anti-oxidant and detoxifying enzyme systems. |
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