Recent advances in transgenic technology |
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Authors: | Ewan R Cameron |
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Institution: | (1) Department of Veterinary Clinical Studies, Glasgow University Veterinary School, Bearsden Road, G61 1QH Glasgow |
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Abstract: | Techniques that allow modification of the mammalian genome have made a considerable contribution to many areas of biological
science. Despite these achievements, challenges remain in two principal areas of transgenic technology, namely gene regulation
and efficient transgenic livestock production. Obtaining reliable and sophisticated expression that rivals that of endogenous
genes is frequently problematic. Transgenic science has played an important part in increasing understanding of the complex
processes that underlie gene regulation, and this in turn has assisted in the design of transgene constructs expressed in
a tightly regulated and faithful manner. The production of transgenic livestock is an inefficient process compared to that
of laboratory models, and the lack of totipotential embryonic stem (ES) cell lins in farm animal species hampers the development
of this area of work. This article highlights recent progress in efficient transgene expression systems, and the current efforts
being made to find alternative means of generating transgenic livestock. |
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Keywords: | Transgenic review mouse gene regulation |
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