Adventitial ablation technique that permits the assessment of adventitial-dependent contribution to microvascular contractile function |
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Authors: | Satirah Zainalabidin Roger M WadsworthPaul Coats |
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Institution: | Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, Scotland, UK |
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Abstract: | Resistance arteries have been implicated as a major contributing factor in the sequela of disease conditions such as hypertension and diabetes and, as such, are a major focus of cardiovascular research. The paracrine influence of the intimal endothelial layer of resistance arteries is well established. Considering the growing body of evidence substantiating a functionally relevant vascular adventitia, in this study we have established a technique that permits determination of the functional influence of the adventitial layer on resistance artery tone. Isolating adventitial-dependent function, analogous to isolating endothelial function, has potentially significant implications for studying the as yet unexplored role of the microvascular adventitial layer in modulating acute vascular contractile function. |
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Keywords: | Microcirculation Adventitia Vasoconstriction Vasorelaxation Pressure autoregulation |
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