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Diabetes mellitus due to misfolding of a beta-cell transcription factor: stereospecific frustration of a Schellman motif in HNF-1alpha |
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| Authors: | Narayana Narendra Phillips Nelson B Hua Qing-xin Jia Wenhua Weiss Michael A |
| Affiliation: | Department of Biochemistry, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106-4935, USA. |
| Abstract: | |
| Keywords: | DCoH, dimerization cofactor of HNF-1 DSC, differential scanning calorimetry GPC, gel-permeation chromatography 4HB, four-helix bundle HNF-1α, hepatocyte nuclear factor-1α HNF-p1, dimerization domain of HNF-1α (residues 1-32) HNF-p1w, dimerization domain of HNF-1α (residues 1-32 extended by Trp at position 33) rp-HPLC, reverse-phase high-performance liquid chromatography MODY, maturity-onset diabetes mellitus of the young PDB, RCSB Protein Data Bank RMSD, root-mean-square deviation. Amino acids are designated by standard single-letter and three-letters codes |
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