Genes on different chromosomes influence the antibody response to bacterial antigens |
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| Authors: | Dr Phillip J Baker Donald W Bailey Michael B Fauntleroy Philip W Stashak George Caldes Benjamin Prescott |
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| Institution: | (1) Laboratory of Microbial Immunity, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 20205 Bethesda, Maryland;(2) Jackson Laboratory, 04609 Bar Harbor, Maine;(3) Biomedical Research Institute, 12111 Parklawn Drive, 20852 Rockville, Maryland;(4) LMI, NIAID, NIH, Building 5, Room 229, 20205 Bethesda, Maryland |
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| Abstract: | B6.C congenic strains of mice, possessing histocompatibility (H) alleles from high responding BALB/cBy (C) mice on the genetic background of low responding C57BL/6By (B6) mice, were assayed for their ability to make an antibody response to Type III pneumococcal polysaccharide (SSS-III) and the  (1 3) epitope of bacterial (Leuconostoc) dextran B-1355. The results affirmed that the antibody response to SSS-III is multigenic and that genes making a positive contribution to responsiveness are located on different chromosomes, i. e., chromosomes 1, 3, 4, 5, and 9. At least one other gene also influences responsiveness to SSS-III; it is linked to the H-17 locus, which has not yet been assigned to a specific chromosome. Genes on chromosomes 1, 4, and 5 influence the magnitude of the antibody response to dextran B-1355. Some of these genes may be antigen-specific in their mode of action; however, others may not since they appear to exert a positive influence on the antibody response to both SSS-III and dextran B-1355. |
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