A multiprotein complex that interacts with RNA polymerase II elongator |
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| Authors: | Li Y Takagi Y Jiang Y Tokunaga M Erdjument-Bromage H Tempst P Kornberg R D |
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| Affiliation: | Department of Structural Biology, Stanford University School of Medicine, Stanford, California 94305-5400, USA. yli@tularik.com |
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| Abstract: | A three-subunit Hap complex that interacts with the RNA polymerase II Elongator was isolated from yeast. Deletions of genes for two Hap subunits, HAP1 and HAP3, confer pGKL killer-insensitive and weak Elongator phenotypes. Preferential interaction of the Hap complex with free rather than RNA polymerase II-associated Elongator suggests a role in the regulation of Elongator activity. |
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