Oxidative stress increases MICA and MICB gene expression in the human colon carcinoma cell line (CaCo-2) |
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| Authors: | Yamamoto K Fujiyama Y Andoh A Bamba T Okabe H |
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| Institution: | Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Otsu, Japan. yamak@belle.shiga-med.ac.jp |
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| Abstract: | The human major histocompatibility complex class I chain-related A gene (MICA) and the MICB gene are newly identified members of the major histocompatibility complex class I chain-related gene family. We demonstrate here that oxidative stress, induced by H(2)O(2), promoted MICA (2.2-fold) and MICB (3.8-fold) gene expression using the human colon carcinoma cell line (CaCo-2) and semi-quantitative RT-PCR. |
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