In vitro and in vivo ACTH-releasing activity of ovine CRF,sauvagine and urotensin I |
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| Authors: | Catherine Rivier Jean Rivier Karl Lederis Wylie Vale |
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| Affiliation: | 1. Peptide Biology Laboratory, The Salk Institute, P.O. Box 85800, San Diego, CA 92138, U.S.A.;2. Department of Pharmacology and Therapeutics, University of Calgary, Calgary, Alberta, Canada |
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| Abstract: | The ability of three homologous peptides, ovine corticotropin-releasing factor (CRF), sauvagine and urotensin I, to release ACTH was examined in vitro and in vivo. All three peptides exhibit statistically equivalent potencies to stimulate ACTH secretion both by cultured pituitary cells and in pharmacology blocked rats. These results suggest that all three peptides evolved from a common mammalian precursor that possessed high hypophysiotropic potency. |
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| Keywords: | CRF sauvagine urotensin I ACTH |
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