| 肝靶向动物模型研究与展望 |
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| 引用本文： | 王楚盈,李超英,张大方. 肝靶向动物模型研究与展望[J]. 中国实验动物学杂志, 2008, 0(2): 63-67 |
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| 作者姓名： | 王楚盈 李超英 张大方 |
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| 作者单位： | 长春中医药大学,吉林长春130117 |
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| 基金项目： | 国家自然基金项目（30472196）. |
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| 摘 要： | 肝癌动物模型是抗肝癌药物实验及肝靶向给药系统验证的重要方法和手段。本文对用于研究肝靶向制剂的动物模型的种类、特征、不足及应用进行了研究论述，提出了目前较适于应用的模型，应用肝癌动物模型可以提供与肝癌病人相似的肝癌生物学特性，也为肝靶向给药制剂药代动力学指标的可靠性提供了保障。
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| 关 键 词： | 肝靶向 模型 动物 |
Liver Targeting Animal Model Studies and Perspective |
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| WANG Chu-ying,LI Chao-ying,ZHANG Da-fang. Liver Targeting Animal Model Studies and Perspective[J]. Chinese Journal of Laboratory Animal Science, 2008, 0(2): 63-67 |
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| Authors: | WANG Chu-ying LI Chao-ying ZHANG Da-fang |
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| Affiliation: | (Changchun University of Chinese Medicine, Changchun 130117, China) |
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| Abstract: | Liver cancer animal models are impertant experimental tools in. studies on liver cancer and to certify targeting drug delivery system. However, in current reports on certificated targeting praeparatum the use of animal models is uncommon. This paper reviewed studies on the model types, features, shortcomings and the application of anti-liver targeting agents animal model, and made more suitable for application of the present models. Application of liver cancer animal models can provide biological characteristics of liver cancer similar to that in patients with liver cancer, and provide reliability of pharmacokinetic indicators for preparation of liver targeted delivery. |
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| Keywords: | Liver targeting Model,animal |
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