转基因EGFP小鼠的主要脏器重量及脏器系数 |
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引用本文: | 田小芸,恽时锋,胡玉红,周森妹. 转基因EGFP小鼠的主要脏器重量及脏器系数[J]. 中国实验动物学杂志, 2008, 0(1): 32-33 |
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作者姓名: | 田小芸 恽时锋 胡玉红 周森妹 |
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作者单位: | 南京军区南京总医院比较医学科,全军实验动物科普与伦理教育基地,南京210002 |
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摘 要: | 目的测定转基因C57BL/6-Tg(ACTB—EGFP)1osb/J(EGFP)小鼠主要脏器重量和脏器系数。方法实验选用5~6周雄性、6~7周雌性小鼠各15只,用sartorius电子天平分别测定体重和9个主要脏器重量,计算脏器系数,并对雌雄脏器重量和脏器系数之间进行比较。结果雌雄小鼠脏器重量间比较,雄性鼠体重明显大于雌性的体重(P〈0.01);心、肝、肺、肾、肾上腺的重量间差异极显著(P〈0.01);脾脏比较差异显著(P〈0.05);雌雄间脏器系数比较,肺、脑、肾上腺间差异极显著(P〈0.01),心、肝、脾、肾脏间差异不显著(P〉0.05)。结论转基因EGFP小鼠不同性别间脏器重量及脏器系数间有一定的差异,为相关研究打下了基础。
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关 键 词: | 转基因小鼠 脏器重量 脏器系数 |
Weight of Main Organs and Organ Coefficient in EGFP Transgenic Mice |
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Affiliation: | TIAN Xia-oyun, YUN Shi-feng, HU Yu-hong, ZHOU Sheng-mei (Department of Compartive Medicine, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, China) |
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Abstract: | Objective To measure the organ weight and organ coefficient of C57BL/6 - Tg(ACTB-EGFP) 1osb/J mice. Methods 5 - 6 weeks male and 6 - 7weeks female 15 mice in each, were used in this experiment.The weight of various organs was measured using a Sartorius BP121S electronic balance. Results Between female and the body weight, the heart, liver, lung, kidney and adrenal weight showed very significant ( P 〈 0.01 ) ; the spleen weight difference ( P 〈 0.05) ; the coefficient of lung, brain, and adrenal showed very significant difference (P 〈 0.01 ), but no significant difference was seen in other organ coefficient. Conclusion The weight of some main organs and organ coefficient in EGFP mice are significantly different ; the above data could be useful in the biomedical researches. |
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Keywords: | Transgenic mice Organ weight Organ coefficient |
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