| TLR4在鼠感染疾病模型的作用机理 |
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| 引用本文： | 弓莉,;王元占,;蔡建平,;杨培梁,;朱玉峰.TLR4在鼠感染疾病模型的作用机理[J].中国实验动物学杂志,2008(12):57-60. |
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| 作者姓名： | 弓莉 ;王元占 ;蔡建平 ;杨培梁 ;朱玉峰 |
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| 作者单位： | [1]南方医院实验动物研究中心,广州510515; [2]广东省农业科学院兽医研究所广东省兽医公共卫生公共实验室,广州510640 |
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| 摘 要： | TLRs是宿主识别各种病原体相关分子模式、并激活和调节天然免疫-适应性免疫反应的一类模式识别受体。在哺乳动物发现13种TLRs成员;已利用近交系小鼠对其作用机理进行了深入研究,本文简要综述TLR4在抗细菌、病毒、寄生虫感染中的作用机理。
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| 关 键 词： | TLRs 感染疾病模型 鼠TLR4 感染 |
Role of TLR4 in the Mechanisms against Infectious Diseases in Mouse Models |
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| Institution: | GONG Li , WANG Yuan-zhan , CAI Jian-ping , YANG Pei-liang , ZHU Yu-feng (1. Centre of Laboratory Animals, Southern Medical University, Guangzhou 510515, China; 2. Laboratory of Veterinary Public Health of Guangdong Province, Institute of Veterinary Medicine, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China) |
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| Abstract: | Toll-like receptors （TLRs）, one of the most important pattern-recognition recaptors （PRRs）, trigger and regulate natural and adapted immunoreaction through the recognition of pathogen-associated molecular patterns （PAMPs）. Up to now, TLRs have been found to have 13 members in mammalians and deeply investigated by infectious models of inbred mice. The review summarized the role of TLR4 in the mechanisms against infection, such as anti-bateria, virus, and parasite. |
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| Keywords: | TLRs Infectious model Mice mTLR4 Infection |
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