| 早老素与阿尔茨海默症的研究进展 |
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| 引用本文： | 方瑾,张连峰,秦川.早老素与阿尔茨海默症的研究进展[J].中国实验动物学杂志,2008(4):70-72. |
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| 作者姓名： | 方瑾 张连峰 秦川 |
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| 作者单位： | 中国医学科学院北京协和医学院医学实验动物研究所,北京100021 |
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| 摘 要： | 早老素（Presenilin,PS）是早发性阿尔茨海默症的风险基因,在外周组织和脑内均有表达。早老素行使多种生物学功能,除了是r-分泌酶的活性基团,还参与信号通路,调控细胞分化与胚胎发育。本综述旨在对早老素的多种生物学功能及其在阿尔茨海默症中的作用进行概述。
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| 关 键 词： | 早老素 阿尔茨海默症 |
Presenilin in Alzheimer Disease--a Review |
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| FANG Jin,ZHANG Lian-feng,QIN Chuan.Presenilin in Alzheimer Disease--a Review[J].Chinese Journal of Laboratory Animal Science,2008(4):70-72. |
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| Authors: | FANG Jin ZHANG Lian-feng QIN Chuan |
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| Institution: | (Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China) |
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| Abstract: | Presenilin （PS）, which expresses widely throughout the brain and peripheral organs, is the high risk gene of Alzheimer disease （AD）. Presenilin has a number of biological functions. In addition to the active group of 7-secretase, PS also regulates cellular differentiation and embryonic development, by taking part in the signaling pathway. This review is to summarize the role of presenilin and its contribution in the neuropathology of AD. |
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| Keywords: | Presenilin Alzheimer disease |
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