慢性支气管炎动物模型研究进展

慢性支气管炎是呼吸系统发病率和死亡率高的一种重要原因，临床和基础研究进展缓慢。吸入烟雾、空气污染物与职业接触慢性刺激传导气道是慢性支气管炎发病的关键因素。近年来虽提出各种各样动物模型，但具实用价值者仍极有限。复制慢性支气管炎动物模型有周期长、个体差异大、检测困难及可靠性差等问题。本文简要介绍烟熏、吸入SO2与气管内滴注脂多糖等最常用的慢性支气管炎动物模型的研究进展。将有益于抗慢性支气管炎药物研究时的更多选择应用。

Development of Animal Models of Chronic Bronchitis

Chronic bronchitis is a significant cause of morbidity and mortality of respiratory diseases, however, the development of clinic and basic research on chronic bronchitis is far from enough. Chronic irritation of the conducting airways by inhaled substances, most importantly cigarette smoke, air pollution, and occupational exposures, is thought to be a key factor in the pathogenesis of chronic bronchitis. In recent years, several animal models of chronic bronchitis have been developed, but their practicality are still limited, because of their long period of preparation, considerable interindividual variation, difficult measurement and uncertain dependability of examined indexes. This paper introduces briefly the research progress of most commonly used animal models of chronic bronchitis,established by tobacco smoke, SO2 and lipopolysaccharide （endotoxin）. Those animal models are useful to provide new idea for the study of chronic bronchitis and development of new anti-chronic bronchitis drugs.